9-deoxy-9-methylene Prostaglandin E2

9-deoxy-9-methylene Prostaglandin E2 (9-deoxy-9-methylene PGE2) is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.

Product Specifications

CAS Number

[61263-32-9]

Product Name Alternative

9-Deoxy-9-methylene PGE2

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/9-deoxy-9-methylene-prostaglandin-e2.html

Smiles

O[C@H]1[C@@H]([C@H](C(C1)=C)C/C=C\CCCC(O)=O)/C=C/[C@H](CCCCC)O

Molecular Formula

C21H34O4

Molecular Weight

350.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bundy, et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv. Prostaglandin Thromboxane Res. 6, 355-363 (1980) .