Human Properdin Protein, His Tag
Human Properdin, His Tag (PRN-H52H3) is expressed from human 293 cells (HEK293) . It contains AA Asp 28 - Leu 469 (Accession # P27918-1) .
Product Specifications
Background
Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates (PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P27918-1
Expression Region
Asp 28 - Leu 469
Host
HEK293
Target
Properdin
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
50.7 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
200ug*5
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/PRN-H52H3.pdf
Species
Human
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