AMG-009

AMG-009 is a potent antagonist of prostaglandin D2, with IC50 of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

Product Specifications

CAS Number

[1027847-67-1]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AMG-009.html

Purity

98.08

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CC=C(OC2=CC=C(C(NCCCC)=O)C=C2NS(=O)(C3=CC=C(Cl)C=C3Cl)=O)C(OC)=C1

Molecular Formula

C26H26Cl2N2O7S

Molecular Weight

581.46

References & Citations

[1]Liu J, et al. Discovery and optimization of CRTH2 and DP dual antagonists. Bioorg Med Chem Lett. 2009 Nov 15;19 (22) :6419-23.|[2]Liu J, et al. Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett. 2011 Mar 2;2 (5) :326-30.|[3]Johnson MG, et al. Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD (2) receptors CRTH2 and DP. Bioorg Med Chem Lett. 2014 Jul 1;24 (13) :2877-80.