GAT2711
GAT2711 is a full agonist of α9 nAChR with an EC50 of 230 nM. GAT2711 shows 340-fold selective for α9 over α7 nAChRs. GAT2711 inhibits ATP-induced IL-1β release in THP-1 cells. GAT2711 retains full analgesic activity in α7 nAChR knockout mice[1].
Product Specifications
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gat2711.html
Purity
98.00
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[N+]1(CC)CCN(C2=CC=C(C=C2)NC(C3=NC(C)=CC=C3)=O)CC1.[I-]
Molecular Formula
C20H27IN4O
Molecular Weight
466.36
References & Citations
[1]Andleeb H, et al. Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation. J Med Chem. 2024 Jun 13;67 (11) :8642-8666.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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