Ketanserin tartrate

Serotonin 5HT2A Antagonist

Product Specifications

Background

A selective serotonin 5-HT2A receptor antagonist (IC50 = 6.3 nM) (1). Also exhibits significant selectivity for the human 5-HT1Dα receptor (2). Was shown to be effective for the treatment of hypertension following coronary artery surgery (3). It has been used to disrupt the hallucinogenic effects of psilocybin and to explore cognitive effects of the 5-HT2A receptor (4).

Product Name Alternative

3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione, tartrate; R41468

UNSPSC

41116105

Source

Synthetic

Purity

>98% (HPLC); NMR (Conforms)

Weight

0.005

Format

White powder

Solubility

May be dissolved in DMSO (30 mg/ml); or Water (5 mg/ml)

Molecular Formula

C22H22FN3O3 • C4H6O6

Molecular Weight

545.5

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Leysen JE., et al. (1981) Life Sci. 28:1015. 2. Zgombick JM., et al. (1995) Eur. J. Pharmacol. 291:9. 3. Vandenbroucke G., et al.(1994) J. Cardiothorac. Vasc. Anesth. 8: P324. 4. Quednow BB.,et al. (2012) Neuropsychopharmacology. 37:630.