Ketanserin tartrate
Serotonin 5HT2A Antagonist
Product Specifications
Background
A selective serotonin 5-HT2A receptor antagonist (IC50 = 6.3 nM) (1). Also exhibits significant selectivity for the human 5-HT1Dα receptor (2). Was shown to be effective for the treatment of hypertension following coronary artery surgery (3). It has been used to disrupt the hallucinogenic effects of psilocybin and to explore cognitive effects of the 5-HT2A receptor (4).
CAS Number
83846-83-7
Product Name Alternative
3-[2-[4- (4-Fluorobenzoyl) -1-piperidinyl]ethyl]-2,4 (1H,3H) -quinazolinedione, tartrate; R41468
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Field of Research
Neuroscience | Neurotransmission | Neurotransmitter Receptors | Ion Channels | Potassium Channels
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White powder
Solubility
May be dissolved in DMSO (30 mg/ml); or Water (5 mg/ml)
Molecular Formula
C22H22FN3O3 • C4H6O6
Molecular Weight
545.5
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Leysen JE., et al. (1981) Life Sci. 28:1015.
2. Zgombick JM., et al. (1995) Eur. J. Pharmacol. 291:9.
3. Vandenbroucke G., et al.(1994) J. Cardiothorac. Vasc. Anesth. 8: P324.
4. Quednow BB.,et al. (2012) Neuropsychopharmacology. 37:630.
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