NoxA1ds

NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC50=20 nM) . NoxA1ds inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors[1].

Product Specifications

CAS Number

[1435893-78-9]

UNSPSC

12352209

Target

NADPH Oxidase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/noxa1ds.html

Purity

97.71

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H]1N(CCC1)C([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C50H88N14O15

Molecular Weight

1125.32

References & Citations

[1]Ranayhossaini DJ, et al. Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem. 2013;288 (51) :36437-36450.