HLY78
Product Specifications
UNSPSC Description
HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].
Target Antigen
Apoptosis; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis;Stem Cell/Wnt
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hly78.html
Purity
98.49
Solubility
DMSO : 26 mg/mL (ultrasonic)
Smiles
CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C
Molecular Weight
267.32
References & Citations
[1]Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.|[2]Luo X, et al. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36(10):1171-1181.|[3]Ma Y, et al. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22(4):688.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122816/HLY78-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122816/HLY78-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
854847-61-3
Available Sizes
Curated Selection
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