HLY78

HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3].

Product Specifications

CAS Number

[854847-61-3]

UNSPSC

12352005

Hazard Statement

H410

Target

Apoptosis; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hly78.html

Purity

98.44

Solubility

DMSO : 26 mg/mL (ultrasonic)

Smiles

CCC1=CC=CC2=C1N(CC3=CC4=C(C=C32)OCO4)C

Molecular Formula

C17H17NO2

Molecular Weight

267.32

Precautions

H410

References & Citations

[1]Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9 (9) :579-85.|[2]Luo X, et al. HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats. Neurosci Bull. 2020 Oct;36 (10) :1171-1181.|[3]Ma Y, et al. Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer. Oncol Lett. 2021 Oct;22 (4) :688.