NLRP3-IN-61

NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC50 of 12.6 nM, inhibits IL-β release with an IC50 of 25.3 nM[1].

Product Specifications

CAS Number

[3060585-94-3]

UNSPSC

12352005

Target

NOD-like Receptor (NLR) ; Pyroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-61.html

Smiles

OC1=C(CCC2)C2=CC(C)=C1C3=CC=C(OC([C@@H]4CCC(NC4)=O)=N5)C5=N3

Molecular Formula

C21H21N3O3

Molecular Weight

363.41

References & Citations

[1]BOUCHE LA, et al., 5-[5- (2-hydroxyphenyl) oxazolo[4,5-b]pyridin-2-yl]piperidin-2-one derivatives as nlpr3 inhibitors for the treatment of inflammatory diseases. WO2024218188