NLRP3-IN-61
NLRP3-IN-61 (Compound 1) is an inhibitor for NLRP3. NLRP3-IN-61 inhibits pyroptosis in THP-1 cell with an IC50 of 12.6 nM, inhibits IL-β release with an IC50 of 25.3 nM[1].
Product Specifications
CAS Number
3060585-94-3
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-61.html
Smiles
OC1=C(CCC2)C2=CC(C)=C1C3=CC=C(OC([C@@H]4CCC(NC4)=O)=N5)C5=N3
Molecular Formula
C21H21N3O3
Molecular Weight
363.41
References & Citations
[1]BOUCHE LA, et al., 5-[5- (2-hydroxyphenyl) oxazolo[4,5-b]pyridin-2-yl]piperidin-2-one derivatives as nlpr3 inhibitors for the treatment of inflammatory diseases. WO2024218188
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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