S-Acetylglutathione

S-Acetylglutathione is a derivative of Glutathione (HY-D0187) . S-Acetylglutathione is stable in blood, and can be converted to glutathione by intracellular thioesterases. S-Acetylglutathione restores the intracellular glutathione content in glutathione synthetase deficient fibroblasts. S-Acetylglutathione exhibits antiviral efficacy in HSV-1 infected model through inhibition of viral replication. S-Acetylglutathione induces apoptosis in cancer cells MOLT4 and UKF-NB-3[1][2][3].

Product Specifications

CAS Number

[3054-47-5]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HSV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/s-acetylglutathione.html

Concentration

10mM

Purity

98.57

Solubility

DMSO : 43.75 mg/mL (ultrasonic)

Smiles

O=C(O)CNC([C@H](CSC(C)=O)NC(CC[C@@H](C(O)=O)N)=O)=O

Molecular Formula

C12H19N3O7S

Molecular Weight

349.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Vogel JU, et al., Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection. Med Microbiol Immunol. 2005 Jan;194 (1-2) :55-9.|[2]Okun JG, et al., S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. J Inherit Metab Dis. 2004;27 (6) :783-6.|[3]Donnerstag B, et al., Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy. Cancer Lett. 1996 Dec 20;110 (1-2) :63-70.