Iniparib
Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer.
Product Specifications
CAS Number
160003-66-7
Product Name Alternative
BSI-201; NSC-746045; IND-71677
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Influenza Virus; PARP
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BSI-201.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C([N+]([O-])=O)=C1)I)N
Molecular Formula
C7H5IN2O3
Molecular Weight
292.03
Precautions
H302, H319
References & Citations
[1]Liu X, et al. Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res. 2012 Jan 15;18 (2) :510-23.|[2]Yin S, et al. Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells. PLoS One. 2017 Aug 17;12 (8) :e0183578.|[3]Ma W, et al. Differential effects of poly (ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc Natl Acad Sci U S A. 2012 Apr 24;109 (17) :6590-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
PARP1
Available Sizes
Frequently Asked Questions
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