CCF0058981
CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].
Product Specifications
CAS Number
2708934-53-4
Product Name Alternative
CCF981
UNSPSC
12352005
Hazard Statement
H315, H319
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ccf0058981.html
Purity
98.02
Solubility
DMSO : 25 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
O=C(N(C1=CC=C(C2=CNC=N2)C=C1)CC3=CC=CC(Cl)=C3)CN4N=NC5=CC=CC=C54
Molecular Formula
C24H19ClN6O
Molecular Weight
442.90
Precautions
H315, H319
References & Citations
[1]Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro) . J Med Chem. 2021 Aug 4; acs.jmedchem.1c00598.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY403676 100 µg
Osteocrin (OSTN) (NM_198184) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC682540-500 1x 500 µL
SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) (SOX4/2540), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
