CCF0058981

CCF0058981 (CCF981), 3-chlorophenyl analogue, is a noncovalent SARS-CoV-2 3CLpro (SC2) inhibitor with an IC50 of 68 nM. CCF0058981 inhibits SC1 (SARS-CoV-1 3CLpro) with an IC50 of 19 nM. CCF0058981 has antiviral efficacy and has the potential for COVID-19 research[1].

Product Specifications

CAS Number

[2708934-53-4]

Product Name Alternative

CCF981

UNSPSC

12352005

Hazard Statement

H315, H319

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ccf0058981.html

Purity

98.02

Solubility

DMSO : 25 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

O=C(N(C1=CC=C(C2=CNC=N2)C=C1)CC3=CC=CC(Cl)=C3)CN4N=NC5=CC=CC=C54

Molecular Formula

C24H19ClN6O

Molecular Weight

442.90

Precautions

H315, H319

References & Citations

[1]Sang Hoon Han, et al. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CL pro) . J Med Chem. 2021 Aug 4; acs.jmedchem.1c00598.