HA-1004 (hydrochloride)
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models[1][2][3][4].
Product Specifications
CAS Number
92564-34-6
UNSPSC
12352005
Target
Calcium Channel; Cyclic GMP-AMP Synthase; ERK; PKA; Tyrosine Hydroxylase
Type
Reference compound
Related Pathways
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ha-1004-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(NCCNC(N)=N)=O.[H]Cl
Molecular Formula
C12H16ClN5O2S
Molecular Weight
329.81
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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