ZNL0325
ZNL0325 is a covalent probe based on pyrazolopyrimidine. ZNL0325 features an acrylamide side chain at the C3 position, which is capable of forming covalent bonds with multiple kinases that possess a cysteine at the αD-1 position, including BTK, EGFR, BLK, and JAK3. ZNL0325 can be used in the research of creating structurally distinct covalent kinase inhibitors[1].
Product Specifications
UNSPSC
12352005
Target
Fluorescent Dye
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/znl0325.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N1C2=NC=NC(N)=C2C(OC3CN(C3)C(C=C)=O)=N1)C
Molecular Formula
C15H20N6O2
Molecular Weight
316.36
References & Citations
[1]Li Z, et al. ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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