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CSF1R-IN-21

CSF1R-IN-21 (compound 7e) is a CSF-1R Inhibitor with an IC50 value of 31 nM. CSF1R-IN-21 inhibits CSF-1R auto-phosphorylation and can be used for the research of neurodegenerative diseases [1].

Product Specifications

CAS Number

[2935479-62-0]

UNSPSC

12352005

Target

C-Fms

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/csf1r-in-21.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NOC(C)=C1)NC2=CC(NC(C3=CC(C(F)(F)F)=CC(N4C(C)=CN=C4)=C3)=O)=CC=C2C

Molecular Formula

C24H20F3N5O3

Molecular Weight

483.44

References & Citations

[1]Baek J, et al. Discovery of N- (5-amido-2-methylphenyl) -5-methylisoxazole-3-carboxamide as dual CSF-1R/c-Kit Inhibitors with improved stability and BBB permeability. Eur J Med Chem. 2024 Feb 20;268:116253.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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