LG190178
Product Specifications
UNSPSC Description
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between VDR and retinoid X receptor (RXR), stabilizing the agonistic conformation of the VDR ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer[1].
Target Antigen
Apoptosis; RAR/RXR; VD/VDR
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lg190178.html
Smiles
OCC(O)COC1=CC=C(C(C2=CC=C(OCC(O)C(C)(C)C)C(C)=C2)(CC)CC)C=C1C
Molecular Weight
458.63
References & Citations
[1]Perakyla, et al. Gene regulatory potential of nonsteroidal vitamin D receptor ligands. Molecular endocrinology 19.8 (2005): 2060-2073.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117182/LG190178-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117182/
Clinical Information
No Development Reported
CAS Number
233268-81-0
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