GW814408X
GW814408X is a kinase chemical genome group (KCGS) compound that inhibits the AURKC kinase involved in cell cycle progression, checkpoint regulation, and cell division. GW814408X exhibits cell line-dependent toxicity, e.g., cytotoxic effects on HeLa cells. GW814408X acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential implications for Fluc reporter assays[1].
Product Specifications
CAS Number
886599-05-9
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gw814408x.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=CNC3=C2N=CN=C3N/N=C/C4=CC=NC=C4)=CC=C1
Molecular Formula
C19H16N6O
Molecular Weight
344.37
References & Citations
[1]Wells CI, et al. The Kinase Chemogenomic Set (KCGS) : An Open Science Resource for Kinase Vulnerability Identification. Int J Mol Sci. 2021 Jan 8;22 (2) :566.|[2]Dranchak P, et al. Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays. PLoS One. 2013;8 (3) :e57888.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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