1-Methoxyphaseollidin

1-Methoxyphaseollidin, a flavonoid compound, is a lysoPAF acetyltransferase inhibitor, with an IC50 of 48 μM. 1-Methoxyphaseollidin exhibits anti-H.pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX) -sensitive strains[1][2][3].

Product Specifications

CAS Number

[65428-13-9]

UNSPSC

12352005

Target

Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/1-methoxyphaseollidin.html

Purity

99.11

Solubility

DMSO : 18 mg/mL (ultrasonic; warming)

Smiles

OC1=CC(OC)=C2[C@@](OC3=C(C/C=C(C)\C)C(O)=CC=C34)([H])[C@@]4([H])COC2=C1

Molecular Formula

C21H22O5

Molecular Weight

354.40

References & Citations

[1]Fukai T, et, al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 Aug 9;71 (12) :1449-63. |[2]Nagumo S, et, al. Inhibition of lysoPAF acetyltransferase activity by components of licorice root. Biol Pharm Bull. 1999 Oct;22 (10) :1144-6.|[3]Sinha SK, et, al. Potential Leads from Liquorice Against SARS-CoV-2 Main Protease using Molecular Docking Simulation Studies. Comb Chem High Throughput Screen. 2021;24 (4) :591-597.