KS-133
Product Specifications
UNSPSC Description
KS-133 is a selective and potent antagonist of vasoactive intestinal peptide receptor 2 (VIPR2), with the IC50 values of 24.8 nM and 500 nM in Ca influx assay and cAMP assay. KS-133 plays an important role in schizophrenia research[1].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ks-133.html
Smiles
O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N(CCC2)[C@]2([H])C3=O)=O)CC(C)C)=O)CC(C=C4)=CC=C4O)=O)[C@@](CCC5)([H])N5C([C@H](CSSC[C@@](NC([C@@H](NC([C@@H](NC6=O)CC(C=C7)=CC=C7O)=O)CC(C)C)=O)([H])C(N[C@@H](CC(NCCCC[C@]6([H])N3)=O)C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)[C@@H](C)CC)=O)=O)=O)NC(C)=O)=O
Molecular Weight
1558.90
References & Citations
[1]Kotaro Sakamoto, et al. Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders. Front Pharmacol. 2021 Nov 4:12:751587.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P6292/KS-133-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P6292/
Clinical Information
No Development Reported
CAS Number
2724212-01-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal RNF70 Antibody [Alexa Fluor 532]](https://cdn.genprice.uk/genprice/genprice4.png)
TA804222AM 100 µL
SP17 (SPA17) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4A2]
Ask
View Details