Factor Xa (Human, Highly Pure)

<strong>Factor Xa (Human, Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010471_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 U_x000D_ <strong>Molecular Weight or Concentration:</strong> na_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure (specific activity ≥170 units/mg protein) Factor Xa from human plasma._x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Coagulation Factor Xa, Human Plasma_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, Mathur VS,_x000D_ Castillo J, Bronson MD, Leeds JM, Mar FA, Gold A, Crowther MA. Andexanet Alfa_x000D_ for the Reversal of Factor Xa Inhibitor Activity. N Engl J Med. 2015 Dec_x000D_ 17;373(25):2413-24._x000D_ _x000D_ 2: Piran S, Khatib R, Schulman S, Majeed A, Holbrook A, Witt DM, Wiercioch W,_x000D_ Schünemann HJ, Nieuwlaat R. Management of direct factor Xa inhibitor-related_x000D_ major bleeding with prothrombin complex concentrate: a meta-analysis. Blood Adv._x000D_ 2019 Jan 22;3(2):158-167._x000D_ _x000D_ 3: Connolly SJ, Crowther M, Eikelboom JW, Gibson CM, Curnutte JT, Lawrence JH,_x000D_ Yue P, Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen_x000D_ AT, Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Demchuk AM, Pallin DJ,_x000D_ Concha M, Goodman S, Leeds J, Souza S, Siegal DM, Zotova E, Meeks B, Ahmad S,_x000D_ Nakamya J, Milling TJ Jr; ANNEXA-4 Investigators. Full Study Report of Andexanet_x000D_ Alfa for Bleeding Associated with Factor Xa Inhibitors. N Engl J Med. 2019 Apr_x000D_ 4;380(14):1326-1335._x000D_ _x000D_ 4: Samama MM. The mechanism of action of rivaroxaban--an oral, direct Factor Xa_x000D_ inhibitor--compared with other anticoagulants. Thromb Res. 2011_x000D_ Jun;127(6):497-504._x000D_ _x000D_ 5: Frontera JA, Bhatt P, Lalchan R, Yaghi S, Ahuja T, Papadopoulos J, Joset D._x000D_ Cost comparison of andexanet versus prothrombin complex concentrates for direct_x000D_ factor Xa inhibitor reversal after hemorrhage. J Thromb Thrombolysis. 2020_x000D_ Jan;49(1):121-131._x000D_ _x000D_ 6: Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A,_x000D_ Bronson MD, Lu G, Conley PB, Verhamme P, Schmidt J, Middeldorp S, Cohen AT,_x000D_ Beyer-Westendorf J, Albaladejo P, Lopez-Sendon J, Goodman S, Leeds J, Wiens BL,_x000D_ Siegal DM, Zotova E, Meeks B, Nakamya J, Lim WT, Crowther M; ANNEXA-4_x000D_ Investigators. Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa_x000D_ Inhibitors. N Engl J Med. 2016 Sep 22;375(12):1131-41._x000D_ _x000D_ 7: Powell J, Taylor J, Garland SG. Andexanet alfa: A Novel Factor Xa Inhibitor_x000D_ Reversal Agent. Ann Pharmacother. 2019 Sep;53(9):940-946._x000D_ _x000D_ 8: Smith MN, Deloney L, Carter C, Weant KA, Eriksson EA. Safety, efficacy, and_x000D_ cost of four-factor prothrombin complex concentrate (4F-PCC) in patients with_x000D_ factor Xa inhibitor-related bleeding: a retrospective study. J Thromb_x000D_ Thrombolysis. 2019 Aug;48(2):250-255._x000D_ _x000D_ 9: Kim KM, Kim J, Baek MC, Bae JS. Novel factor Xa inhibitor, maslinic acid,_x000D_ with antiplatelet aggregation activity. J Cell Physiol. 2020_x000D_ Dec;235(12):9445-9456._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32738161/">10: Nederpelt CJ, Naar L, Sylvester KW, Barra ME, Roberts RJ, Velmahos GC,_x000D_ Kaafarani HMA, Rosenthal MG, King DR. Evaluation of oral factor Xa inhibitor-_x000D_ associated extracranial bleeding reversal with andexanet alfa. J Thromb Haemost._x000D_ 2020 Oct;18(10):2532-2541. </a>_x000D_ _x000D_ <strong>Products Related to Factor Xa (Human, Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>