DBM-C5-VC-PAB-MMAE

DBM-C5-VC-PAB-MMAE (Compound 3a) is a Drug-Linker conjugate for ADC. DBM-C5-VC-PAB-MMAE is composed of a linker C5-VC-PAB with a maleimide group DBM and an ADC toxin MMAE (HY-15162) [1].

Product Specifications

CAS Number

[1644228-55-6]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbm-c5-vc-pab-mmae.html

Purity

99.45

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN4C(C(Br)=C(C4=O)Br)=O)=O)=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C68H103Br2N11O15

Molecular Weight

1474.42

References & Citations

[1]Feuillâtre O, et al., Impact of Maleimide Disubstitution on Chemical and Biological Characteristics of HER2 Antibody-Drug Conjugates. ACS Omega. 2020 Jan 17;5 (3) :1557-1565.