Folinic acid (Standard)

Folinic acid (Standard) is the analytical standard of Folinic acid. This product is intended for research and analytical applications. Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].

Product Specifications

CAS Number

[58-05-9]

Product Name Alternative

Leucovorin (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Endogenous Metabolite; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/folinic-acid-standard.html

Purity

98.21

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O

Molecular Formula

C20H23N7O7

Molecular Weight

473.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397 (2) : p. 221-8.|[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92 (12) :1438-44.