Leflunomide
Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
Product Specifications
CAS Number
75706-12-6
Product Name Alternative
HWA486; RS-34821; SU101
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Bacterial; Dihydroorotate Dehydrogenase; Endogenous Metabolite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/leflunomide.html
Purity
99.82
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2
Molecular Formula
C12H9F3N2O2
Molecular Weight
270.21
Precautions
H301, H315, H319, H335
References & Citations
[1]Davis JP, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35 (4) :1270-3.|[2]Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270 (21) :12398-403.|[3]Fox RI, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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