Leflunomide

Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.

Product Specifications

CAS Number

[75706-12-6]

Product Name Alternative

HWA486; RS-34821; SU101

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Bacterial; Dihydroorotate Dehydrogenase; Endogenous Metabolite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/leflunomide.html

Purity

99.82

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(C1=C(C)ON=C1)NC2=CC=C(C(F)(F)F)C=C2

Molecular Formula

C12H9F3N2O2

Molecular Weight

270.21

Precautions

H301, H315, H319, H335

References & Citations

[1]Davis JP, et al. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 1996 Jan 30;35 (4) :1270-3.|[2]Xu X, et al. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270 (21) :12398-403.|[3]Fox RI, et al. Mechanism of action for leflunomide in rheumatoid arthritis. Clin Immunol. 1999 Dec;93 (3) :198-208.