IA-Alkyne

IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection[1]. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling[2]. IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[930800-38-7]

Product Name Alternative

Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

UNSPSC

12352211

Hazard Statement

H301, H311, H331, H341

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ia-alkyne.html

Concentration

10mM

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCCCC#C)CI

Molecular Formula

C8H12INO

Molecular Weight

265.09

Precautions

H301, H311, H331, H341

References & Citations

[1]David L. Use of trp channel agonists to treat infections. Patent US20130203715A1.|[2]Zorin NA, et al. Inhibition by iodoacetamide and acetylene of the H-D-exchange reaction catalyzed by Thiocapsa roseopersicina hydrogenase. Eur J Biochem. 1996 Oct 15;241 (2) :675-81.