Suchilactone
Suchilactone (Jatrophan) is a lignan extracted from Monsonia angustifolia E.Mey. Suchilactone binds to SHP2 and inhibits SHP2 activation, thereby inhibiting ERK-mediated cell proliferation. Suchilactone can be ued in acute myeloid leukaemia (AML) [1].
Product Specifications
CAS Number
50816-74-5
Product Name Alternative
Jatrophan
UNSPSC
12352005
Target
SHP2
Type
Natural Products
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/suchilactone.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1C[C@H](COC/2=O)C2=C/C3=CC=C(OCO4)C4=C3)=C(C=C1)OC
Molecular Formula
C21H20O6
Molecular Weight
368.38
References & Citations
[1]Wu J, et al. Suchilactone inhibits the growth of acute myeloid leukaemia by inactivating SHP2. Pharm Biol. 2022 Dec;60 (1) :144-153.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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