QKY-613
Product Specifications
UNSPSC Description
QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of cGAS and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms[1].
Target Antigen
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Infection;Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/qky-613.html
Smiles
CNC1=C2C(N(C3O[C@@H]([C@H](C3)O)COP(OC4=CC=CC=C4)(N[C@@H](C)C(OCC5=CC=CC=C5)=O)=O)C=N2)=NC=N1
Molecular Weight
582.54
References & Citations
[1]Wang N, et al. Host RNA N6-methyladenosine and incoming DNA N6-methyldeoxyadenosine modifications cooperatively elevate the condensation potential of DNA to activate immune surveillance. Mol Ther. 2024 Dec 4;32(12):4418-4434.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159925/QKY-613-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159925/
Clinical Information
No Development Reported
CAS Number
2484713-92-8
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