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Corosolic acid (Standard)

Corosolic acid (Standard) is the analytical standard of Corosolic acid. This product is intended for research and analytical applications. Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3].

Product Specifications

CAS Number

4547-24-4

Product Name Alternative

Colosolic acid (Standard)

UNSPSC

12352211

Target

Apoptosis; Autophagy; EGFR; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/corosolic-acid-standard.html

Smiles

O[C@H]1[C@H](O)C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5)([H])[C@]3(C)C1

Molecular Formula

C30H48O4

Molecular Weight

472.70

References & Citations

[1]Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64 (5) :468-70.|[2]LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 
 2015-08|[3]Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015
 , 29 (5) : 14–723|[4]Ma B, et al. Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. J Exp Clin Cancer Res. 2018 Sep 3;37 (1) :210.|[5]Zhang BY, et al. Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. Br J Pharmacol. 2021 Mar;178 (6) :1475-1491. |[6]Yang J, et al. Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. Phytomedicine. 2016 Feb 15;23 (2) :181-90.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

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