What is the catalog number for SAP15?

The catalog number for SAP15 is HY-P10462.

What sizes are available for SAP15?

SAP15 is available in the following size(s): 1 Each.

SAP15 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SAP15?

SAP15 is manufactured by QuantiMol.

What is the estimated delivery time for SAP15?

Estimated delivery time for SAP15 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SAP15?

The safety data sheet for SAP15 is available here: http://file.medchemexpress.com/batch_PDF/HY-P10462/.

SAP15

SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials[1].

Product Specifications

CAS Number

1403753-45-6

Product Name Alternative

Synthetic anti-inflammatory peptide 15

UNSPSC

12352209

Target

HDAC; NF-κB

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sap15.html

Smiles

O=C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C68H131N31O18S3

Molecular Weight

1767.16

References & Citations

[1]Lee J Y, et al. Engineered synthetic cell penetrating peptide with intracellular anti‐inflammatory bioactivity: An in vitro and in vivo study[J]. Journal of Biomedical Materials Research Part A, 2021, 109 (10) : 2001-2016.