Bim-IN-1

Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity[1].

Product Specifications

CAS Number

[2909483-36-7]

Product Name Alternative

MK-591

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bim-in-1.html

Purity

99.57

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC1=CC(C2N(S(=O)(CC3=CC=C(Cl)C=C3Cl)=O)CCCCC2)=CC=C1

Molecular Formula

C19H20Cl2FNO2S

Molecular Weight

416.34

References & Citations

[1]Richards BJ, et al. Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model. Bioorg Chem. 2022; 120:105635.