Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MS78

Product Specifications

UNSPSC Description

MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].

Target Antigen

Histone Acetyltransferase; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis;Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms78.html

Solubility

DMSO : 135 mg/mL (ultrasonic)

Smiles

CC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1

Molecular Weight

1024.25

References & Citations

[1]Kabir M, et al. Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-149306/MS78-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-149306/MS78-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

3034773-00-4

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Anti-MARS1 Antibody Picoband® (Dylight488 Conjugate)
A00216-1-Dylight488 100 μg

Anti-MARS1 Antibody Picoband® (Dylight488 Conjugate)

Ask
View Details
Porcine Ceruloplasmin ELISA Kit
E07C0090-01 48 Well

Porcine Ceruloplasmin ELISA Kit

Ask
View Details
Porcine Ceruloplasmin ELISA Kit
E07C0090-02 96 Well

Porcine Ceruloplasmin ELISA Kit

Ask
View Details
Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit
MBS7619339-01 48 Well

Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit

Ask
View Details
Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit
MBS7619339-02 96 Well

Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit

Ask
View Details
Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit
MBS7619339-03 5x 96 Well

Rat CD68 (Cluster of Differentiation 68) QuickTest ELISA Kit

Ask
View Details