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MS78

Product Specifications

UNSPSC Description

MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].

Target Antigen

Histone Acetyltransferase; MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis;Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms78.html

Solubility

DMSO : 135 mg/mL (ultrasonic)

Smiles

CC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1

Molecular Weight

1024.25

References & Citations

[1]Kabir M, et al. Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-149306/MS78-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-149306/MS78-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

3034773-00-4

Available Sizes

Curated Selection

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