MS78
Product Specifications
CAS Number
[3034773-00-4]
UNSPSC Description
MS78 is an acetylation targeting chimera (AceTAC) that acetylates the p53 tumor suppressor protein. MS78 recruits histone acetyltransferase p300/CBP to acetylate the p53Y220C mutant. MS78 upregulates TRAIL apoptotic genes and downregulates DNA damage response pathways. MS78 contains a CBP/p300 binder, a p53Y220C binder and a linker[1].
Target Antigen
Histone Acetyltransferase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms78.html
Solubility
DMSO : 135 mg/mL (ultrasonic)
Smiles
CC1=CSC(C2=CC=C(C3=C2)C4=C(N3CC)C=CC(CNCCOCCOCCOCCN5C=C(N=N5)COC6=C(C=C(C=C6)CCC7=NC8=C(N7CCN9CCOCC9)C=CC(C%10=C(ON=C%10C)C)=C8)F)=C4)=C1
Molecular Weight
1024.25
References & Citations
[1]Kabir M, et al. Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. J Am Chem Soc. 2023 Jul 12;145(27):14932-14944.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
Available Sizes
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