Zaltoprofen

Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC50s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain[1][2][3].

Product Specifications

CAS Number

[74711-43-6]

Product Name Alternative

CN100

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zaltoprofen.html

Purity

99.28

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(C1=CC=C(SC2=C3C=CC=C2)C(CC3=O)=C1)C(O)=O

Molecular Formula

C17H14O3S

Molecular Weight

298.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawai S, et, al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol. 1998 Apr 17;347 (1) :87-94.|[2]Hirate K, et, al. Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res. 2006 Apr;54 (4) :288-94.|[3]Kameyama T, et, al. Analgesic and antiinflammatory effects of 2- (10,11-dihydro-10-oxo-dibenzo[b, f]thiepin-2-yl) propionic acid in rat and mouse. Arzneimittelforschung. 1987 Jan;37 (1) :19-26.