Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1
Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 (Compound 3) is a "linker-payload" component of an antibody-drug conjugate (ADC). Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 selectively delivers the dual-function BTK degrader to B-cell malignancies by targeting the monoclonal antibody of CD79b. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 can be coupled to the engineered CD79b antibody with cysteine, forming CD79b-3 ADC (ADC linker: ; Protac: (HY-163295) ).
Product Specifications
UNSPSC
12352005
Target
PROTAC-Linker Conjugates for PAC; Transmembrane Glycoprotein
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-btk-degrader-8.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C80H94F2N14O20P2
Molecular Weight
1671.63
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD50 (ICAM-3) (186-2G9), CF640R conjugate, 0.1mg/mL
CD81 / TAPA-1 (1.3.3.22), CF405S conjugate, 0.1mg/mL
