BCR-ABL-IN-10
BCR-ABL-IN-10 (compound B4) is a covalent and aryl vinyl sulfate (AVS) -containing BCR-ABL inhibitor with an IC50 of 43.1 nM for ABL kinase. BCR-ABL-IN-10 forms a covalent and stable adduct with ABL kinase, leading to sustained inhibition of endogenous BCR-ABL activities. BCR-ABL-IN-10 can be used for the study of chronic myeloid leukemia (CML) [1].
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcr-abl-in-10.html
Smiles
COC(C(C1=CNC2=NC=C(C=C12)C3=CC(C(N(C)C)=O)=CN=C3)=C4)=CC=C4OS(C=C)(=O)=O
Molecular Formula
C24H22N4O5S
Molecular Weight
478.52
References & Citations
[1]Jie Sun, et al. Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies. J Adv Res. 2024 Sep 8:S2090-1232 (24) 00392-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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