Carbamazepine-d10

Carbamazepine-d10 is the deuterium labeled Carbamazepine. Carbamazepine (CBZ), a sodium channel blocker, is an anticonvulsant agent[1][2].

Product Specifications

CAS Number

[132183-78-9]

Product Name Alternative

CBZ-d10; NSC 169864-d10

UNSPSC

12352005

Hazard Statement

H225, H301+H311+H331, H370

Target

Autophagy; Mitophagy; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Purity

99.53

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC(N1C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])=C([2H])C3=C([2H])C([2H])=C([2H])C([2H])=C31)=O

Molecular Formula

C15H2D10N2O

Molecular Weight

246.33

Precautions

H225, H301+H311+H331, H370

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22 (3) : p. 627-35.|[3]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28 (2) : p. 143-53.