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Anti-Interleukin-1 Receptor (IL-1R) Antibody

Mouse Monoclonal Antibody specific to Interleukin-1 receptor

Product Specifications

Product Name Alternative

IL-1R-1, IL-1RT-1, IL-1RT1, EC 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptor α, IL-1R-α, Interleukin-1 receptor type I, p80, CD antigen CD121a [Cleaved into: Interleukin-1 receptor type 1, membrane form

Gene Name

IL1R1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=IL1R1">IL1R1</a>

UniProt

P14778

Cellular Locus

Membrane, Cell membrane, Secreted

Host

Mouse

Reactivity

Human

Immunogen

The extracellular domain of the type I human IL-1 receptor (Genzyme Diagnostics).

Target Antigen

Interleukin-1 receptor type 1

Target

Interleukin-1 Receptor (IL-1R)

Clonality

Monoclonal

Isotype

IgG2b

Type

Antibody

Applications

ELISA, IHC, RIA

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850). {PubMed:10653850, PubMed:10671496}.

Additionnal Information

ELISA: Can be used as capture reagents or second antibody at a concentration of 5 ug/ml <br><br>RIA: Concentrations of 20-30 ng/ml of these antibodies will bind radiolabeled IL-1 receptor in a radioimmunoassay format. <br><br>Immunohistochemistry: IL-1 receptor can be detected on cultured cells using antibody concentrations of 10-100 ug/ml.

Storage Conditions

These antibodies are stable for at leastone (1) year at -20°C to -70 C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/40101-40103.pdf

Specificity

These antibodies react with cell surface and soluble human IL-1 receptor; Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4.

Formulation

PBS, pH 7.4

Buffer pH

pH 7.4

CAS Number

9007-83-4

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