DK419

DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].

Product Specifications

CAS Number

[2102672-22-8]

UNSPSC

12352005

Target

CDK; c-Myc; Survivin; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dk419.html

Purity

99.86

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3

Molecular Formula

C16H8ClF6N3O

Molecular Weight

407.70

References & Citations

[1]Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26 (20) :5435-5442.