DK419
DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
Product Specifications
CAS Number
[2102672-22-8]
UNSPSC
12352005
Target
CDK; c-Myc; Survivin; Wnt; β-catenin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dk419.html
Purity
99.86
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
Molecular Formula
C16H8ClF6N3O
Molecular Weight
407.70
References & Citations
[1]Wang J, et al. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Nov 1;26 (20) :5435-5442.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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