Butaprost
Butaprost is a selective prostaglandin E receptor (EP2) agonist with an EC50 of 33 nM and a Ki of 2.4 μM for murine EP2 receptor. Butaprost is less activity against murine EP1, EP3 and EP4 receptors. Butaprost attenuates fibrosis by hampering TGF-β/Smad2 signalling[1][2][3].
Product Specifications
CAS Number
69685-22-9
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Prostaglandin Receptor; TGF-beta/Smad
Type
Reference compound
Related Pathways
GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/butaprost.html
Concentration
12.24 mM * 200 μL in Methyl acetate
Purity
99.2
Solubility
10 mM in DMSO
Smiles
COC(CCCCCC[C@@H](C(C[C@H]1O)=O)[C@H]1/C=C/C[C@@H](C2(CCC2)CCC)O)=O
Molecular Formula
C24H40O5
Molecular Weight
408.57
Precautions
H225, H319, H336
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
Available Sizes
Frequently Asked Questions
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