VU0486846
VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) [1].
Product Specifications
CAS Number
[1788055-11-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0486846.html
Purity
99.5
Smiles
O[C@@H](CCCC1)[C@H]1NC([C@@H](C2)OC3=CC=CC=C3N2CC4=CC=C(N5C=CC=N5)C=C4)=O
Molecular Formula
C25H28N4O3
Molecular Weight
432.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Bertron JL, et al. The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core. Bioorg Med Chem Lett. 2018 Jul 1;28 (12) :2175-2179.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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