ROCK2-IN-9
ROCK2-IN-9 (compound 7u) is a selective ROCK2 inhibitor (IC50=36.8 nM) with anticancer activity. ROCK2-IN-9 inhibits cancer cell migration and invasion by regulating multiple cellular activities of the actin cytoskeleton. ROCK2-IN-9 can be used in breast cancer research[1].
Product Specifications
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rock2-in-9.html
Smiles
CC(C=C1)=CC=C1CN(CC2)CCN2C3=NC4=C(C(OCC)=O)C=NN4C(NC5=CC=C(NN=C6)C6=C5)=C3
Molecular Formula
C28H30N8O2
Molecular Weight
510.59
References & Citations
[1]Zhi Cao, et al. "Discovery of novel pyrazolo [1, 5-a] pyrimidine derivatives as selective ROCK2 inhibitors with anti-breast cancer migration and invasion activities." Bioorganic Chemistry (2024) : 107675.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040031-500 1x 500 µL
Mucin 5AC (MUC5AC) (45M1), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680040-500 1x 500 µL
CD35 / CR1 (E11), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470633-100 1x 100 µL
Von Willebrand Factor (3E2D10), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470178-500 1x 500 µL
CD50 (ICAM-3) (186-2G9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details