N-Acetyldesloratadine
N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM. N-Acetyldesloratadine can be used for the study of allergic diseases, such as asthma[1].
Product Specifications
CAS Number
[117796-52-8]
Product Name Alternative
SCH-37370
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histamine Receptor; Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/n-acetyldesloratadine.html
Purity
99.93
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCN(CC\4)C(C)=O)=C1
Molecular Formula
C21H21ClN2O
Molecular Weight
352.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26 (12) :1172-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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