Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Samidorphan (hydrochloride)

Samidorphan hydrochloride is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan hydrochloride acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan hydrochloride primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals[1].

Product Specifications

CAS Number

2328045-02-7

Product Name Alternative

ALKS-33 (hydrochloride) ; RDC-0313 (hydrochloride)

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/samidorphan-hydrochloride.html

Smiles

O[C@@]12[C@]3(CC(CC2)=O)C4=C(O)C(C(N)=O)=CC=C4C[C@@]1([H])N(CC3)CC5CC5.Cl

Molecular Formula

C21H27ClN2O4

Molecular Weight

406.90

References & Citations

[1]McElroy SL, et al. A placebo-controlled pilot study of the novel opioid receptor antagonist ALKS-33 in binge eating disorder. Int J Eat Disord. 2013 Apr;46 (3) :239-45.|[2]Mark S. Todtenkopf, et al. Buprenorphine in Combination with Samidorphan (ALKS 33) Results in Antidepressive-Like Effects in Two Distinct Rat Models. Eur Neuropsychopharmacol. 2014;24aSuppl 2) :S366.|[3]Rehan ST, et al. Samidorphan/olanzapine combination therapy for schizophrenia: Efficacy, tolerance and adverse outcomes of regimen, evidence-based review of clinical trials. Ann Med Surg (Lond) . 2022 Jun 30;79:104115.|[4]Shravni V, et al. Comparative Effects of Buprenorphine and Samidorphan on Locomotor Behavior in vivo. Scientific Research Journal of Pharmacy 2021, Volume 1, Issue: 1 (June-July) .|[5]Smith KL, et al. Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. Neuropharmacology. 2019 Mar 1;146:316-326.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CYTH2, 1-399aa, Human, His tag, E.coli
E53A01822 50 µg

CYTH2, 1-399aa, Human, His tag, E.coli

Sign In for Pricing
View Details
Mouse Monoclonal TAFA3/FAM19A3 Antibody (460904) [Alexa Fluor 488]
FAB4677G 0.1 mL

Mouse Monoclonal TAFA3/FAM19A3 Antibody (460904) [Alexa Fluor 488]

Sign In for Pricing
View Details
20-200μL Ordinary Pipette Tips, Clear, Non-Sterile, 1000pcs*20bags/Carton
21081405 20000 PCS

20-200μL Ordinary Pipette Tips, Clear, Non-Sterile, 1000pcs*20bags/Carton

Sign In for Pricing
View Details
Lentiviral human CBY1 shRNA (UAS) - Lentiviral human CBY1 shRNA (UAS, iRFP) (25)
GTR15325637 1 Vial

Lentiviral human CBY1 shRNA (UAS) - Lentiviral human CBY1 shRNA (UAS, iRFP) (25)

Sign In for Pricing
View Details
Cy3 Linked Monoclonal Antibody to Aquaporin 4 (AQP4)
MBS2130316-01 0.1 mL

Cy3 Linked Monoclonal Antibody to Aquaporin 4 (AQP4)

Sign In for Pricing
View Details
Cy3 Linked Monoclonal Antibody to Aquaporin 4 (AQP4)
MBS2130316-02 0.2 mL

Cy3 Linked Monoclonal Antibody to Aquaporin 4 (AQP4)

Sign In for Pricing
View Details