Dooku1
Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].
Product Specifications
CAS Number
2253744-54-4
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Piezo Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dooku1.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2
Molecular Formula
C13H9Cl2N3OS
Molecular Weight
326.20
Precautions
H315, H319, H335
References & Citations
[1]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175 (10) :1744-1759.|[2]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175 (10) :1744-1759.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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