Dooku1

Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].

Product Specifications

CAS Number

[2253744-54-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Piezo Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dooku1.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=CC=CN3)O2

Molecular Formula

C13H9Cl2N3OS

Molecular Weight

326.20

Precautions

H315, H319, H335

References & Citations

[1]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175 (10) :1744-1759.|[2]Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175 (10) :1744-1759.