TGFβ1-IN-1
Product Specifications
UNSPSC Description
TGFβ1-IN-1 (compound 42) is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies[1].
Target Antigen
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tgfβ1-in-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1CCCC1)C2=CC=CC(NC(/C=C/C3=CC=C(OC)C=C3)=O)=C2
Molecular Weight
364.44
References & Citations
[1]Lin Yue, et al. Discovery and evaluation of phenacrylanilide derivatives as novel potential anti-liver fibrosis agents. Eur J Med Chem. 2022 Nov 15;242:114685.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151427/TGFβ1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151427/TGFβ1-IN-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2348795-14-0
Available Sizes
Curated Selection
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