TGFβ1-IN-1

TGFβ1-IN-1 (compound 42) is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies[1].

Product Specifications

CAS Number

[2348795-14-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tgfβ1-in-1.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1CCCC1)C2=CC=CC(NC(/C=C/C3=CC=C(OC)C=C3)=O)=C2

Molecular Formula

C22H24N2O3

Molecular Weight

364.44

Precautions

H302, H315, H319

References & Citations

[1]Lin Yue, et al. Discovery and evaluation of phenacrylanilide derivatives as novel potential anti-liver fibrosis agents. Eur J Med Chem. 2022 Nov 15;242:114685.