Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

LY404039

LY404039 is a potent, selective and orally active mGluR2 and mGluR3 agonist with Kis of 149 nM and 92 nM for recombinant human mGluR2 and mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects[1].

Product Specifications

CAS Number

635318-11-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/LY404039.html

Purity

98.0

Solubility

DMSO : 3.84 mg/mL (ultrasonic; warming) |H2O : 5.2 mg/mL (ultrasonic; adjust pH to 6 with NaOH)

Smiles

O=C([C@]1(N)CS([C@@]2([H])[C@H](C(O)=O)[C@@]12[H])(=O)=O)O

Molecular Formula

C7H9NO6S

Molecular Weight

235.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Linda M Rorick-Kehn, et al. Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-) - (1R,4S,5S,6S) -4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039) . J Pharmacol Exp Ther. 2007 Apr;321 (1) :308-17.|[2]Seeman P. An agonist at glutamate and dopamine D2 receptors, LY404039. Neuropharmacology. 2013 Mar;66:87-8.|[3]Rorick-Kehn LM, et al. In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonistLY404039 in animal models of psychiatric disorders. Psychopharmacology (Berl) . 2007 Jul;193 (1) :121-36.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

MGluR2; mGluR3

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]
E-AB-F0987M-01 50 Tests

Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]
E-AB-F0987M-02 100 Tests

Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]

Sign In for Pricing
View Details
Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]
E-AB-F0987M-03 2x 100 Tests

Elab Fluor® 647 Anti-Mouse CD161/NK1.1 Antibody[PK136]

Sign In for Pricing
View Details
Pure Goat Anti-Human IgA Gel Specific Immobilized Antibodies
AG-003-2 2 mL

Pure Goat Anti-Human IgA Gel Specific Immobilized Antibodies

Sign In for Pricing
View Details
Glass-Coated Multi-Well Plates
DP22VS-9-GC10 10 Plates/Pack

Glass-Coated Multi-Well Plates

Sign In for Pricing
View Details
RAB4A Polyclonal Antibody
E-AB-66100-01 60 µL

RAB4A Polyclonal Antibody

Sign In for Pricing
View Details