SOS1 Ligand intermediate-7
SOS1 Ligand intermediate-7 (65) is an intermediate for the synthesis of SOS1 ligand. SOS1 activator 1 (HY-111671) can be used for the synthesis of PROTAC SOS1 degrader-1 (HY-145737).
Product Specifications
CAS Number
2836274-66-7
UNSPSC
12352005
Target
Drug Intermediate; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/sos1-ligand-intermediate-7.html
Smiles
CC1=NC2=C(C=C(C(OC)=C2)O)C(N[C@H](C)C3=CC(N)=CC(C(F)(F)F)=C3)=N1
Molecular Formula
C19H19F3N4O2
Molecular Weight
392.37
References & Citations
[1]Yan Lv, et al/ A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor. J Med Chem. 2024 Feb 22;67 (4) :2487-2511.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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